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NFL Week 16 ‘Monday Night Football’ game picks and open thread

Week 16 of the 2023 NFL season wraps up with Monday Night Football featuring the Baltimore Ravens taking on the San Francisco 49ers. Read on for our picks and predictions.

San Francisco 49ers v Baltimore Ravens Photo by Scott Taetsch/Getty Images

Happy holidays from The Falcoholic crew! Week 16 of the 2023 NFL season is almost behind us, with a trio of Christmas Day games taking place today. Our Atlanta Falcons pulled off a Christmas miracle by dominating the Indianapolis Colts, but will still need a few more miracles to have a chance to make the playoffs.

For tonight’s Monday Night Football, we’ve got a real banger on the way with the Baltimore Ravens taking on the San Francisco 49ers.

Let’s get right to tonight’s picks, which I’ll be making on a straight moneyline (aka picking the winner) basis. I’ll still provide the information on the spread and over/under, for those interested. At the bottom, I’ll show the rest of the staff’s picks for the game.

All odds are taken from DraftKings Sportsbook and are subject to change. See the current odds here.

Monday Night Football: Baltimore Ravens (11-3) at San Francisco 49ers (11-3)

The pick: 49ers (-238)

Spread: 49ers -6 | Over/Under: 47 | Moneyline: 49ers -290, Ravens +235

Could this be the game of the year? We’ve got a real banger for the Christmas Day Monday Night Football game, and it could be a potential Super Bowl preview. The top seed in the AFC travels to face the top seed in the NFC, and I’m expecting some fireworks. I’m honestly a little surprised at how big the line is, but the 49ers are the rightful favorite at home. I hope we’re in for a treat!

Staff picks

What are your picks and predictions for tonight’s Monday Night Football matchup?

Odds/lines subject to change. T&Cs apply. See for details.